ABSTRACT
Objective To explore the clinical curative effect and safety of intra -abdominal beacizumab bead sheet resistance combined with hyperthermic intraperitoneal chemotherapy in treatment of ovarian cancer perito-neal effusion.Methods 60 patients with ovarian cancer peritoneal effusion in Binzhou Central Hospital from June 2012 to July 2015 were randomly divided into two groups.30 cases in the control group were treated with intraperito-neal hyperthermic perfusion chemotherapy, while 30 patients in the observation group were given intra-abdominal beacizumab bead sheet resistance combined with hyperthermic intraperitoneal chemotherapy.The short-term effica-cy,toxicity and quality of life were compared.Results The effective rate of the observation group was 73.33%, which was significantly higher than 53.33% in the control group,the difference was significant (χ2 =8.55,P0 .0 5 ) .The improvement rate of life quality of the observation group was 76.67%,which was significantly higher than 50.00%of the control group,the difference was significant (χ2 =8.06,9.31,all P<0.05).Conclusion Intra-abdominal beacizumab bead sheet resistance combined with hyperthermic intraperitoneal chemotherapy has remarkable curative effect in treatment of ovarian cancer peritoneal effusion,with high safety,and can significantly improve the quality of life of patients,that is suitable for clinical application.
ABSTRACT
Objective To investigate the clinical efficacy of uterine artery chemoembolization combined with radiotherapy in the treatment of intermediate and advanced cervical cancer.Methods Eighty patients with intermediate and advanced cervical cancer were randomly divided into treatment group and control group by random digits table with 40 patients each.The patients in treatment group were received uterine artery chemoembolization and radiotherapy.The patients in control group were received radiotherapy and intravenous chemotherapy.The short-term efficacy,survival and untoward reaction were observed in 2 groups.Results The complete remission rate and objective response rate in treatment group were significantly higher than those in control group [72.5％(29/40) vs.50.0％(20/40),95.0％(38/40) vs.80.0％(32/40),P ＜ 0.05].There was no significant difference in survival rate of 1,2 and 3-year between the 2 groups (P ＞ 0.05).The incidence rates of leukopenia,anemia,thrombocytopenia,nausea and vomiting in treatment group were significantly lower than those in control group [32.5％ (13/40) vs.67.5％ (27/40),30.0％ (12/40) vs.75.0％ (30/40),7.5％ (3/40) vs.17.5％ (7/40),37.5％ (15/40) vs.70.0％ (28/40),P ＜0.05].There were no significant difference in the incidence rates of radiation cystitis and radiation proctitis between the 2 groups (P ＞ 0.05).Conclusion Uterine artery chemoembolization combined with radiotherapy for intermediate and advanced cervical cancer can improve short-term efficacy and with less side effects.
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Objective To study the expression and clinical significance of serum levels of transforming growth factor-31 (TGF-β1) and tumor necrosis factor-alpha(TNF-α) in patients with hypertensive disorder complicating pregnancy(HDCP).Methods The serum levels of TGF-β1 and TNF-αin 50 cases with HDCP and 30 cases of normal third trimester pregnant women(control group) were detected by ELISA.50 cases with HDCP were divided into gestational hypertension group,mild preeclampsia group and severe preeclampsia group according to the severity of HDCP.Results The serum levels of TGF-β1 and TNF-α in HDCP patients were significantly higher than the control group (t =13.283,13.607,all P ＜ 0.05).The serum levels of TGF-β1 and TNF-α gradually increased with the aggravating of HDCP disease,the serum levels of TGF-β1 and TNF-αwere significantly different among the three subgroups of HDCP(P ＜ 0.05).The correlation analysis showed that the serum levels of TGF-β1,TNF-α were positively correlated with the severity of HDCP (r =0.575,0.512,all P ＜ 0.05),there was significantly positive correlation between the serum TGF-β1 and TNF-α(r =0.515,P ＜0.05).Conclusion The serum levels of TGF-β1 and TNF-α were high in the HDCP patients,the high levels of TGF-β1 and TNF-α can reflect the changes and development of HDCP disease.The abnormal levels of TGF-β1 and TNF-α may be associate with dysfunction of trophoblast cell.
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To investigate the rehabilitating effect of acupuncture plus kinetotherapy for early hemiplegia due to cerebral apoplexy. Methods:Fifty cases of apoplectic hemiplegia were treated by acupuncture plus kinetotherapy and were compared with another fifty cases treated by single medications,in the therapeutic effect and for follow-up observation. Results:After the treatment for one month on average,the remarkable effective rate was 82% in the rehabilitation group and 54% in the control group,in a significant difference (P＜0.05). After the treatment,the scores in the motor function of the limbs and daily life ability were obviously increased in the rehabilitation group,and there was a significant difference in comparison with the control group (P＜0.05). Moreover,there was a good regulatory effect on blood rheology and blood lipid in the rehabilitation group. Conclusion:A combination of acupuncture and kinetotherapy has a better effect on apoplectic hemiplegia than single medications.